Histamine Intolerance And The Paleo Diet

Histamine is a biogenic amine that occurs (in differing amounts) in many foods. In a person without an intolerance, exogenous histamine obtained via food can be rapidly detoxified by amine oxidases. In subjects with an intolerance, there is usually low amine oxidase activity. Diamine oxidase (DAO) is the primary enzyme which metabolizes dietary histamine. Below is a comprehensive list detailing the kinds of foods that may cause reactions in individuals with low amine oxidase activity or commonly referred to as histamine intolerance.

Astute readers will note this list contains histamine-rich foods, as well as histamine-releasing foods. There are other causes of histamine intolerance, besides having low DAO activity including ˜leaky gut, among other commonly exhibited symptoms as seen in the second table.

Diagnosing a histamine intolerance can be a bit tricky in that you can be tested for allergies, and have negative test results across the board, yet still be histamine intolerant. This is a case where the best method of action, is to follow a low histamine diet for a time period, and then slowly re-introduce foods which provoke a histamine response.

Since your body produces histamine it is best to think of histamine intolerance as an overflow type of situation. Exogenous sources of histamine put your body over the edge. Other causes of histamine intolerance include: allergies, GI bleeding, and small intestinal bacterial overgrowth (SIBO). Endogenous histamine is so important that histaminergic neurons may form part of a €œflipflop switch hypothesized to regulate sleep and wakefulness It is also important to note that antipsychotic drugs can interact with H1 histamine receptors, and may lead to weight gain. In cases of asthma, histamine can modulate the cytokine network through up regulation of prostaglandin E and nitric oxide. Then there is the case of atopic dermatitis, which can be improved via a low histamine diet. There are also studies, which show that modulation of histamine receptors (specifically H1 receptors) can affect actual dietary intake.

Histamine-induced food intolerance is not IgE-mediated. This means again that the best way to improve a histamine intolerance is to follow a low histamine diet, which can easily be done within a Paleo Diet framework. Diamine oxidase cannot be supplemented; so lowering your histamine intake via food is the best method of action. As stated in this study, the only effective long-term therapy for a histamine intolerance is the avoidance of histamine-containing food.


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This article originally appeared on The Paleo Diet.